Chemical Synthesis Of γ-aminobutyric Acid

The more important chemical syntheses are mainly as follows: the first is to use potassium phthalimide and γ-chlorobutyronitrile or butyrolactone as raw materials for making GABA, and the final product obtained after violent reaction and hydrolysis is GABA; the second is to use pyrrolidone as the initial raw material, and hydrolyze it with calcium hydroxide and ammonium bicarbonate, and the final product obtained by opening the ring is GABA; the third is to use butyric acid and ammonia as the raw materials of GABA, The fourth method is to use propylamine and formic acid to synthesize GABA by the method of glow discharge; the fifth method is to use methyl bromoacetate and ethylene as the preparation of GABA The raw material of 4-bromobutyrate is obtained by polymerization, and the final product after ammonolysis and hydrolysis is GABA. The chemical synthesis methods of GABA all have the disadvantages that the reaction is not easy to control and the cost is relatively high.